hrp0095p1-87 | Fat, Metabolism and Obesity | ESPE2022

Thyroid Disfunctions During Pediatric Obesity: Possible Role in Obese Children with Insulin Resistance

Salvatore Guercio Nuzio , D'Isanto Livio

Introduction: Pediatric obesity (PO) is associated with hormonal dysfunctions contributing to an increased risk of cardiovascular disease and diabetes. Among these risks, thyroid disfunctions (TD) are the most common. The ethio-pathogenetic mechanisms underlying TD are not well known and include an adaptive response to a higher energy intake, hyperleptinemia, peripheral resistance to thyroid hormones, increased pro-inflammatory cytokines. Pediatric prevalence ...